STATE_TRANSITION
DP1*:E2F1_Lys_ace:PCAF@nucleus - CDK2_Thr160_pho:cyclin A2*@nucleus -> DP1*__pho:E2F1__pho_Lys_ace:PCAF@nucleus
(center map)
Comments:
PMID:15840440 Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation). PMID:15133492 PMID:9556498 PMID:15123636 Phosphorylation of both DP-1 and E2F1 PMID:16135794 Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation. PMID:11980909 Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb. PMID:16213134
In modules:
- Module: CycA2:CDK2
- Module: E2F1-3