(1) CASP6 - cleaved~CASP3 -> cleaved~CASP6 (2) CASP8 - cleaved~CASP6 - HIP1:IFT57 - FADD:MT-CO2:TRADD -> cleaved~CASP8 (3) cleaved~CASP6 -t-> cleaved~CASP6@nucleus (4) cleaved~CASP6 -> active~caspase