(center map) (center map)PMID:9108473 purification of DFFA DFFB activity from Hela cells cytosol in vitro, CASP3 mediated of DFFA necessary for nucleosomal DNA fragmentation in U937 monocyte cells, in Hela cells, in SV589 human fibroblasts, upon staurosporin, DFFA cleaved into the same fragments as in vitro PMID:9422506 purification and cloning of ICAD CAD (mouse homologs) from mouse T-cell lymphoma cytosol CASP3-mediated cleavage of ICAD releases CAD, leading to activation of its enzymatic activity and its nuclear localization