STATE_TRANSITION(re640)

BAD|S91_unk:BCL2@mitochondrial outer membrane - RAF1 -> BCL2@mitochondrial outer membrane+BAD|pho
center map on reaction (center map)
Comments:

PMID:8929532 in vitro RAF1 BCL2 interaction in 293, overexpression of BCL2 induces relocalization of RAF1-GFP to mitochondria in vitro phosphorylation of BAD by RAF1 in 293T, over-expression of a mitochondria-targeted version of RAF1 induces phosphorylation of BAD (controls plasma membrane targeted RAF1, kinase dead mutant) BCL2 over-expression targets RAF1 kinase domain-GFP to mitochondria mitochondria-targeted RAF1 (deleted for Ras binding domain) potentiates BCL2 anti-apoptotic activity in 32D.3 exposed to staurosporine or upon IL-3 withdrawal


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