STATE_TRANSITION(re630)

BAD|unk - CDK1 -> BAD|S91_pho|unk
center map on reaction (center map)
Comments:

PMID:12049737 in vitro with recombinant murine proteines in COS cells with ectopic expression of BAD in rat granule neurons upon suppression of neuronal activity, cdc2 is induced, phosphorylates BAD S128 in rat neurones expressing ectopic proteins, cdc2 induced apoptosis is inhibited by a BAD S118 mutant in vitro, AKT mediated BAD S136 phosphorylation is not blocked by prior cdc2 mediated BAD S128 phosphorylations BAD S128 phosphorylation inhibits BAD phospho S136 14-3-3 interaction


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