(center map) (center map)PMID:10671558 in vitro with recombinant proteins cleavage of recombinant CASP9 by cellular extract, in a Ca2+ dose-dependent manner in Hela cell extracts, preincubation with Ca2+ and CAPN2 prevents Cyt_c-mediated CASP3 cleavage in SH-SY5Y human neuroblastoma cells Ca2+ ionophore (A23187) treatment CAPN2-cleaved CASP9 is inactive CASP78 are also cleaved by CAPN2, but the effect on their activity is unknown