STATE_TRANSITION(re484)

CASP9 - (d)ATP:APAF1:CYCS - BIRC5|T34_pho:HBXIP - NOD1 -> cleaved~CASP9
center map on reaction (center map)
Comments:

PMID:15210107 reviews the differerent hypothesis concerning the biochemical events leading to activation of CASP9 PMID:12773388 in vitro, survivin and HBXIP together inhibits CASP9 processing and activation in HT1080 cells, coexpression of BIRC5 and HBXIP suppresses staurosporin-induced apoptosis in cell extracts from Hela transfected with siRNA against HBXIP, CYCS induced caspase activation is suppressed PMID:10329646 by NOD1


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