STATE_TRANSITION(re436)

BimEL* - ERK* -> BimEL*|S69_pho
center map on reaction (center map)
Comments:

PMID:12646560 in CCL39 chinese hamster lung fibroblast cell line PMID:15486085 in IL-3 dependent mouse pro-B cell line FL5.12, upon IL-3, ERK dependent phosphorylation of BimEL on S55, S65, S100 (mouse Bim) in vitro, ERK2 phosphorylates mouse BimEL in mouse BAF3 cells, in TF-1 human granulocyte macrophage- colony stimulating factor-dependent er ythroleukemia cell line, and in mouse embr yonic fibroblasts when IGF-1 was used as a survival factor, an upshift in BimEL (not BimL) electrophoretic mobility upon IL3. This upshift is lost in FL5.12 if phosphosites are mutated. PMID:19150432


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