STATE_TRANSITION(re387)

HIF1A+O_sub_2_endsub_+2-oxoglutarate - succinate - fumarate - Fe_super_2+_endsuper_:PHD* - OS9 -> HIF1A|P564_hyd+succinate+CO_sub_2_endsub_
center map on reaction (center map)
Comments:

PMID:12351678 identification of PHD2 as a HIF1A prolyl hydroxylase PMID:15652751 inhibition of HIF1A prolyl hydroxylation by succinate and fumarate PMID:15721254 in 293 cells, OS9 interacts with HIF1 and PHD and promotes HIF1A prolylhydroxylation and degradation


In modules: