(center map) (center map)PMID:10973499 in vitro reconstitution of the E3-ligase activity, with VHL, elonginB/C, RBX1,CUL2 PMID:18985005 in COS monkey kidney cells and Caki-I human renal carcinoma cells, inhibition of VHL-mediated HIF1A ubiquitinylation and degradation by ectopically expressed constitutively active STAT3