STATE_TRANSITION(re375)

- (MLST8:MTOR:RPTOR|unk)||active - BECN1|T119_unk - PIK3C3 - DRAM1 -> autophagy
center map on reaction (center map)
Comments:

PMID:15146184 inhibition relieved in mouse model of Huntington disease, where mTOR is inhibited by sequestration into polyglutamine aggregates PMID:16839881 p53 target gene DRAM1 is necessary for induction of autophagy


In modules: