STATE_TRANSITION(re1409)

BCL2@mitochondrial outer membrane - PRKCA - ERK* - JNK*|Y185_pho|T183_pho -> BCL2|pho@mitochondrial outer membrane
center map on reaction (center map)
Comments:

PMID:9115213 S70 phosphorylation of BCL2 necessary for its antiapoptotic function in NSF/N1.H7 mouse leukemia cells BCL2 mutants transfection) in response to IL-3, etoposide, or bryostatin-1, a PKC activator PMID:9738012 suggest that PRKCA is the main PRKC BCL2 kinase in HL60 human acute myeloid leukemia cell line PMID:10677502 ERK1/2 is a BCL2 S70 kinase in NSF/N1.H7 cells stimulated with IL-3 in vitro direct phosphorylation PMID:11323415 JNK is a BCL2 S70 kinase in NSF/N1.H7 cells upon IL-3 withdrawal


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