PMID:18208354 TP53 downregulates the activity of the MCL1 gene promoter in Hela and HEK293 mainly through an unkown mechanism. Critical importance of the -41 to +16 region that correspond to TATA-BP and other basal transcription factors binding also through down regulation of Sp1 PMID:19808698 in MV4-11 cells, a human biphenotypic B myelomonocytic leukemia that displays FLT3-ITD mutation (constitutive FLT3 signalling), STAT5* siRNA prevents MCL1 expression PMID:11160159 in large granular lymphocyte high STAT3 activity correlates with MCL1 expression, AG-490 JAK inhibitors induce apoptosis and decreases MCL1 expression. in NIH3T3, upon v-src, STAT3 dependent expression of MCL1