(center map) (center map)PMID:12234250 in G361 human melanoma cells, upon ionizing radiations in vitro by ATM and DNAPK in Hela, ectopically expressed LKB1 T366-phosphorylated is located in the nucleus PMID:20160076 in HeLa S3 cells that lack functional LKB1, reexpression of wild-type but not T366A LKB1 restored the ability to repress mTORC1 in response to H2O2 in MCF7, LKB1 is located in the cytoplasm, together with a proportion of ATM. H2O2 induces phosphorylation of cytoplasmic LKB1, but not other DNA damaging agents (etoposide). This supports a possible H2O2-induced and DNA damage-independent activation of the cytoplasmic of ATM responsible for LKB1 phosphorylation.