STATE_TRANSITION(re93)

MT-CO1@mitochondrial inner membrane+COX5A@mitochondrial inner membrane+COX6A*@mitochondrial inner membrane+COX5B@mitochondrial inner membrane+COX7A*@mitochondrial inner membrane+heme a@mitochondrial matrix+MT-CO3@mitochondrial inner membrane+Cu_super_2+_endsuper_:MT-CO2@mitochondrial inner membrane - SURF1@mitochondrial inner membrane -> COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu_super_2+_endsuper_:MT-CO1:MT-CO2:MT-CO3:heme a@mitochondrial inner membrane
center map on reaction

(center map)

Comments:

PMID:15119951 SURF1 mutations are associated with Leigh syndrome (cytochrome oxidase deficiency) PMID:11389896 SURF1 Homolog of Yeast (Shy) is necessary for COX assembly and stability PMID:19625251 Paroccocus denitrificans SURF1 homologs were proposed to promote heme a insertion into COX subunit 1

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