Demo Data: Mitogen-activated protein kinase (MAPK) cascade

Huang CHF, Ferrell Jr JE: Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA, 1996, 93: 10078-10083.

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The model is available as SBML module that can be imported in JDesigner to simulate idealistic time series. Visit also EMBL-EBI BioModels.

Network Structure (copy and paste from JDesigner)

Model (copy and paste from JDesigner)

Exemplary Time Series used for the Inference

Idealistic time series (100 time points) generated by JDesigner were subsequently distorted by time sampling, leaving 19 time points at random time intervals, and by adding statistical noise with the noise-to-signal level: 0.05. Click on the image to download the time series.